Pubblicazioni
S.S.D. Ematologia
2012
- Breda L, Casu C, Gardenghi S, Bianchi N, Cartegni L, Narla M, Yazdanbakhsh K, Musso M, Manwani D, Little J, Gardner LB, Kleinert DA, Prus E, Fibach E, Grady RW, Giardina PJ, Gambari R, Rivella S. Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients. PLoS One. 2012;7(3):e32345. Epub 2012 Mar 27.
- Forni GL, Perrotta S, Giusti A, Quarta G, Pitrolo L, Cappellini MD, D'Ascola DG, Borgna Pignatti C, Rigano P, Filosa A, Iolascon G, Nobili B, Baldini M, Rosa A, Pinto V, Palummeri E. Neridronate improves bone mineral density and reduces back pain in β-thalassaemia patients with osteoporosis: results from a phase 2, randomized, parallel-arm, open-label study. Br J Haematol. 2012 Jul;158(2):274-82.
- Gianesin B, Zefiro D, Musso M, Rosa A, Bruzzone C, Balocco M, Carrara P, Bacigalupo L, Banderali S, Rollandi GA, Gambaro M, Marinelli M, Forni GL. Measurement of liver iron overload: noninvasive calibration of MRI-R2* by magnetic iron detector susceptometer. Magn Reson Med. 2012 Jun;67(6):1782-6.
- Neufeld EJ, Galanello R, Viprakasit V, Aydinok Y, Piga A, Harmatz P, Forni GL, Shah FT, Grace RF, Porter JB, Wood JC, Peppe J, Jones A, Rienhoff HY Jr. A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload. Blood. 2012 Apr 5;119(14):3263-8.
- Pelucchi S, Mariani R, Calza S, Fracanzani AL, Litta Modignani G, Bertola F, Busti F, Trombini P, Fraquelli M, Forni GL, Girelli D, Fargion S, Specchia C, Piperno A. CYBRD1 as a modifier gene that modulates iron phenotype in HFE p.C282Y homozygous patients. Haematologica. 2012 Dec;97(12):1818-25.
2011
- Abbruzzese G, Cossu G, Balocco M, Marchese R, Murgia D, Melis M, Galanello R, Barella S, Matta G, Ruffinengo U, Bonuccelli U, Forni GL. A pilot trial of deferiprone for neurodegeneration with brain iron accumulation. Haematologica. 2011 Jul 26.
- Carpenter JP, He T, Kirk P, Roughton M, Anderson LJ, de Noronha SV, Sheppard MN, Porter JB, Walker JM, Wood JC, Galanello R, Forni G, Catani G, Matta G, Fucharoen S, Fleming A, House MJ, Black G, Firmin DN, St Pierre TG, Pennell DJ. On T2* magnetic resonance and cardiac iron. Circulation. 2011 Apr 12;123(14):1519-28.
- Derchi G, Formisano F, Balocco M, Galanello R, Bina P, Dessì C, Piga A, Donato G, Cappellini MD, Cassinerio E, Quarta G, Melpignano A, Forni GL. Clinical management of cardiovascular complications in patients with thalassaemia major: a large observational multicenter study. Eur J Echocardiogr. 2011 Mar;12(3):242-6.
- Foppiani L, Cella A, Carrara P, Balocco M, Forzano F, Leone D, Ivaldi G, Bacigalupo L, Del Monte P. Osteoporosis in an elderly man as interplay of multiple diseases. Geriatr Gerontol Int. 2011 Jan;11(1):123-6.
- Martinoli C, Bacigalupo L, Forni GL, Balocco M, Garlaschi G, Tagliafico A. Musculoskeletal manifestations of chronic anemias. Semin Musculoskelet Radiol. 2011 Jul;15(3):269-80.
- Piga A, Serra M, Longo F, Forni G, Quarta G, Cappellini MD, Galanello R. Changing patterns of splenectomy in transfusion-dependent thalassemia patients. Am J Hematol. 2011 Sep;86(9):808-10.
- Porter JB, Lin KH, Beris P, Forni GL, Taher A, Habr D, Domokos G, Roubert B, Thein SL; on behalf of the EPIC study investigators. Response of iron overload to deferasirox in rare transfusion-dependent anaemias: equivalent effects on serum ferritin and labile plasma iron for haemolytic or production anaemias. Eur J Haematol. 2011 Jun 7.
- Punzo F, Bertoli-Avella AM, Scianguetta S, Della Ragione F, Casale M, Ronzoni L, Cappellini MD, Forni G, Oostra BA, Perrotta S. Congenital Dyserythropoietic Anemia Type II: molecular analysis and expression of the SEC23B Gene. Orphanet J Rare Dis. 2011 Dec 30;6:89.
- Vichinsky E, Bernaudin F, Forni GL, Gardner R, Hassell K, Heeney MM, Inusa B, Kutlar A, Lane P, Mathias L, Porter J, Tebbi C, Wilson F, Griffel L, Deng W, Giannone V, Coates T. Long-term safety and efficacy of deferasirox (Exjade(®) ) for up to 5 years in transfusional iron-overloaded patients with sickle cell disease. Br J Haematol. 2011 Aug;154(3):387-397.
2010
- Balocco M, Carrara P, Pinto V, Forni GL. Daily alternating deferasirox and deferiprone therapy for "hard-to-chelate" beta-thalassemia major patients. Am J Hematol. 2010 Jun;85(6):460-1.
- Bonino F, Arena U, Brunetto MR, Coco B, Fraquelli M, Oliveri F, Pinzani M, Prati D, Rigamonti C, Vizzuti F. Liver Stiffness Study Group 'Elastica' of the Italian Association for the Study of the Liver. Liver stiffness, a non-invasive marker of liver disease: a core study group report. Antivir Ther. 2010;15 Suppl 3:69-78. (Forni GL)
- Carrara P, Balocco M, Pinto V, Olcese F, Soldà A, Strada P, Forni GL. Manual erythroexchange for chronic transfusion therapy in patients with sickle cell syndromes unresponsive to hydroxyurea: A long-term follow-up. Am J Hematol. 2010 Dec;85(12):974.
- Castiglioni E, Finazzi D, Goldwurm S, Levi S, Pezzoli G, Garavaglia B, Nardocci N, Malcovati L, Porta MG, MG, Gallì A, Forni GL, Girelli D, Maccarinelli F, Poli M, Ferrari M, Cremonesi L, Arosio P. Sequence Variations in Mitochondrial Ferritin: Distribution in Healthy Controls and Different Types of Patients. Genet Test Mol Biomarkers. 2010 Oct 12.
- Castiglioni E, Finazzi D, Goldwurm S, Pezzoli G, Forni G, Girelli D, Maccarinelli F, Poli M, Ferrari M, Cremonesi L, Arosio P. Analysis of nucleotide variations in genes of iron management in patients of Parkinson's disease and other movement disorders. Parkinsons Dis. 2010 Oct 17;2011:827693.
- Fracchia E, Elkababri M, Cantello C, Gori A, Partsch H, Forni GL. Venous-like leg ulcers without venous insufficiency in congenital anemia: successfultreatment using compression bandages. Dermatol Surg. 2010 Aug;36(8):1336-40.
- Gattermann N, Finelli C, Porta MD, Fenaux P, Ganser A, Guerci-Bresler A, Schmid M, Taylor K, Vassilieff D, Habr D, Domokos G, Roubert B, Rose C; EPIC study investigators. Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study. Leuk Res. 2010 Sep;34(9):1143-50. (Forni GL)
- Lee JW, Yoon SS, Shen ZX, Ganser A, Hsu HC, Habr D, Domokos G, Roubert B, Porter JB; EPIC study investigators. Iron chelation therapy with deferasirox in patients with aplastic anemia: a subgroup analysis of 116 patients from the EPIC trial. Blood. 2010 Oct 7;116(14):2448-54. (Forni GL)
- Marinelli M, Gianesin B, Balocco M, Beruto P, Bruzzone C, Carrara P, Gallusi P, Macco A, Musso M, Oliveri E, Pelucchi S, Sobrero G, Villa R, Forni GL. Total iron-overload measurement in the human liver region by the magnetic iron detector. IEEE Trans Biomed Eng. 2010 Sep;57(9):2295-303.
- Marinelli M, Gianesin B, Balocco M, Bruzzone C, Carrara P, Musso M, Oliveri E, Pelucchi S, Sobrero G, Forni G. Total iron overload measurement in human liver region by magnetic iron detector (MID). IEEE Trans Biomed Eng. 2010 Jun 17
- Origa R, Piga A, Quarta G, Forni GL, Longo F, Melpignano A, Galanello R. Pregnancy and beta-thalassemia: an Italian multicenter experience. Haematologica. 2010 Mar;95(3):376-81.
- Russo R, Esposito MR, Asci R, Gambale A, Perrotta S, Ramenghi U, Forni GL, Uygun V, Delaunay J, Iolascon A. Mutational spectrum in congenital dyserythropoietic anemia type II: Identification of 19 novel variants in SEC23B gene. Am J Hematol. 2010 Dec;85(12):915-20.
2009
- Fabbri E, Forni GL, Guerrini G, Borgna-Pignatti C.
Pseudoxanthoma elasticum-like syndrome and thalassemia: an update. Dermatol Online J. 2009 Jul 15;15(7):7. - Forni GL, Puntoni M, Boeri E, Terenzani L, Balocco M.
The influence of treatment in specialized centers on survival of patients with thalassemia major. Am J Hematol. 2009 May;84(5):317-8. - Origa R, Galanello R, Perseu L, Tavazzi D, Domenica Cappellini M, Terenzani L, Forni GL, Quarta G, Boetti T, Piga A.
Cholelithiasis in thalassemia major. Eur J Haematol. 2009 Jan;82(1):22-5. - Origa R, Piga A, Quarta G, Forni GL, Longo F, Melpignano A, Galanello R.
Pregnancy and {beta}-thalassemia: an Italian multicenter experience. Haematologica. 2009 Nov 10. - Pepe A, Positano V, Capra M, Maggio A, Pinto CL, Spasiano A, Forni G, Derchi G, Favilli B, Rossi G, Cracolici E, Midiri M, Lombardi M.
Myocardial scarring by delayed enhancement cardiovascular magnetic resonance in thalassaemia major. Heart. 2009 Oct;95(20):1688-93.
2008
- Vichinsky E, Pakbaz Z, Onyekwere O, Porter J, Swerdlow P, Coates T, Lane P, Files B, Mueller BU, Coïc L, Forni GL, Fischer R, et all. Patient-reported outcomes of deferasirox (Exjade, ICL670) versus deferoxamine in sickle cell disease patients with transfusional hemosiderosis. Substudy of a randomized open-label phase II trial. Acta Haematol. 2008;119(3):133-41
- Forni GL, Girelli D, Lamagna M, Mori M, Marinaro E, Campostrini N, Carrara P. et all Acquired iron overload associated with antitransferrin monoclonal immunoglobulin: A case report. Am J Hematol. 2008 Dec;83(12):932-4
- Forni GL, Balocco M, et all. Regression of symptoms after selective iron chelation therapy in a case of neurodegeneration with brain iron accumulation. Mov Disord. 2008 Apr 30;23(6):904-7
- Galanello R, Piga A, Cappellini MD, Forni GL, Zappu A, et all. Effect of food, type of food, and time of food intake on deferasirox bioavailability: recommendations for an optimal deferasirox administration regimen. J Clin Pharmacol. 2008 Apr;48(4):428-35
- Biasiotto G, Camaschella C, Forni GL, Polotti A, et all. New TFR2 mutations in young Italian patients with hemochromatosis. Haematologica. 2008 Feb;93(2):309-10
- Porter J, Galanello R, Saglio G, Neufeld EJ, Vichinsky E, Cappellini MD, Olivieri N, Piga A, Cunningham MJ, Soulières D, Gattermann N, Tchernia G, Maertens J, Giardina P, Kwiatkowski J, Quarta G, Jeng M, Forni GL, et all. Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study. Eur J Haematol. 2008 Feb;80(2):168-76
- Ramazzotti A, Pepe A, Positano V, Scattini B, Santarelli MF, Landini L, De Marchi D, Keilberg P, Derchi G, Formisano F, Pili M, Lai ME, Forni G, et all. Standardized T2* map of a normal human heart to correct T2* segmental artefacts; myocardial iron overload and fibrosis in thalassemia intermedia versus thalassemia major patients and electrocardiogram changes in thalassemia major patients. Hemoglobin. 2008;32(1-2):97-107
2007
- Positano V, Pepe A, Santarelli MF, Scattini B, De Marchi D, Ramazzotti A, Forni G, Borgna-Pignatti C, Lai ME, Midiri M, Maggio A, Lombardi M, Landini L. Standardized T2* map of normal human heart in vivo to correct T2* segmental artefacts. NMR Biomed. 2007 Oct;20(6):578-90
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Vichinsky E, Onyekwere O, Porter J, Swerdlow P, Eckman J, Lane P, Files B, Hassell K, Kelly P, Wilson F, Bernaudin F, Forni GL, Okpala I, Ressayre-Djaffer C, Alberti D, Holland J, Marks P, Fung E, Fischer R, Mueller BU, Coates T; Deferasirox in Sickle Cell Investigators. A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease. Br J Haematol. 2007 Feb;136(3):501-8
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Vassanelli A, Lodi G, Forni G, Cabibbo S, Pennisi A, Perseghin P, De Meis I, Messina R, Pani M, Poma R, Guastella G, Lunghi M, Mazzoni A, Capuzzi E, Denti A, Perotti C, Sassi M, Mariano MT, Dal Canton, Multicentric retrospective study on erythroexchange in sikle cell disease. Preliminary rusults. Haematologica. 2007 Oct. 92(3):16:17
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Porter J, Galanello R, Saglio G, Neufeld EJ, Vichinsky E, Cappellini MD,Olivieri N, Piga A, Cunningham MJ, Soulières D, Gattermann N, Tchernia G,Maertens J, Giardina P, Kwiatkowski J, Quarta G, Jeng M, Forni GL, Stadler M, Cario H, Debusscher L, Della Porta M, Cazzola M, Greenberg P, Alimena G, Rabault B, Gathmann I, Ford JM, Alberti D, Rose C. Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study. Eur J Haematol. 2007 Nov 17
2006
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Borgna-Pignatti C, Cappellini MD, DiStefano P, Del Vecchio GC, Forni GL, Gamberini MR, Ghilardi R, Piga A, Romeo MA, Zhao H, Cnaan A. Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major. Blood, 2006 May 1;107(9):3733-7
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Marinelli M, Cuneo S, Gianesin B, Lavagetto A, Lamagna M, Oliveri E, Sobrero G, Terenzani L, Forni GL. Non - invasive measurement of iron overload in the human body. IEEE Transactions on Applied Superconductivity, VOL. 16, No. 2, June 2006
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Piga A, Galanello R, Forni GL, Cappellini MD, Origa R, Zappu A, Donato G, Bordone E, Lavagetto A, Zanaboni L, Sechaud R, Hewson N, Ford JM, Opitz H, Alberti D. Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, im comparison to deferoxamine in thalassemia patients with trasfusional iron overload. Haematologica 2006; 91:873-880
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R.Galanello, A. Piga, G. L. Forni, Y. Bertran, M. L. Foschini, E. Bordone, G.B. Leoni, A. Lavagetto, A. Zappu, F. Longo, H. Maseruka, N Latham, R. Sechaud, R. Belleli and D. Alberti. Phase II clinical evaluation of deferairox (Exjade®, ICL670), a once-daily oral chelating agent, in paediatric patiens with β-thalassaemia major. Haematologica, 2006; 91:1343-51
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Marinelli M, Beruto P, Gianesin B, Lavagetto A, Lamagna M, Oliveri E, Saccone ML, Sobrero G, Terenzani L, Forni GL. Whole Liver Iron Overload Measurement by magnetic Iron Detector (MID). A Non Cryogenic Bio-Susceptometer. Blood, Vol. 108, issue 11, Nov 2006
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E. Vichinsky, O. Onyekwere, J. Porter, P. Swerdlow, J. Eckman, P. Lane, B. Files, K. Hassell, P. Kelly, F. Wilson, F. Bernaudin, G. L. Forni, I.Okpala, C. Ressayre-Djaffer, D. Alberti, J. Holland, P. Marks, E. Fung, R. Fischer, B. U. Mueller and T. Coates for the Deferasirox in Sickle Cell Investigators. A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease. British Journal of Haematology, 2006: 136, 501-508
2005
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Derchi G, Forni GL, Formisano F, Cappellini MD, Galanello R, D'Ascola G, Bina P, Magnano C, Lamagna M. Efficacy and safety of sildenafil in the treatment of severe pulmonary hypertension in patients with hemoglobinopathies Haematologica, 2005 Apr; 90(4):452-8
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Jambrik Z, Derchi G, Picano E, Ait-Ali L, Forni GL, Bellotti P. Lack of prognostic value of normalized integrated backscatter analysis of myocardium in patients with thalassemia major: a long-term follow-up study Echocardiography. 2005 Mar; 22(3):239-44
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Derchi G, Forni G.L. Therapeutic Approaches to Pulmonary Hypertension in Hemoglobinopathies: efficacy and safety of sildenafil in the treatment of severe pulmonary hypertension in patients with hemoglobinopathy Ann. N.Y. Acad. Sci. 1054: 471-475 (2005)
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Borgna-Pignatti C, Cappellini MD, De Stefano P, Del Vecchio GC, Forni GL, Gamberini MR, Ghilardi R, Origa R, Piga A, Romeo MA, Zhao H, Cnaan A. Survival and complications in thalassemia Ann N Y Acad Sci.2005 Nov; 1054:40-7
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Forni GL, Ivaldi G Inquadramento diagnostico delle emoglobinopatie alla luce dei flussi migratori Haematolologica vol. 90, suppl. n.4, 52-53 Sept 2005
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Forni GL L'impiego dell'ICL 670 (deferasirox) nella terapia ferro chelante Haematolologica vol. 90, suppl. n. 4, 71-72 Sept 2005
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Laura Cemonesi, Gian Luca Forni, Nadia Soriani, Martina Lamagna, Isabella Fermo, Filomena Daraio, Anna Galli, Daniela Pietra, Maurizio Ferrari, Clara Camaschella & Mario Cazzola. Genetic and clinical heterogeneity of ferroportin disease Br J Haematol. 2005 Dec;131(5):663-70
2004
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Borgna-Pignatti C, Vergine G, Lombardo T, Cappellini MD, Cianciulli P, Maggio A, Renda D, Lai ME, Mandas A, Forni G, Piga A, Bisconte MG. Hepatocellular carcinoma in the thalassaemia syndromes Br J Haematol. 2004 Jan;124(1):114-117.
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G.L. Forni Pseudoxanthoma elasticum and clinical syndromes peculiar to thalassemia In "Clinical Aspects and Therapy of Thalassemia" A.Maggio- A.V. Hoffbrand, Chapter 5, ed. SEU, 2004
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Borgna-Pignatti C, Rugolotto S, De Stefano P, Zhao H, Cappellini MD, Del Vecchio GC, Romeo MA, Forni GL, Gamberini MR, Ghilardi R, Piga A, Cnaan A. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine Haematologica, 2004 Oct; 89(10):1187-93
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Prati D, Maggioni M, Milani S, Cerino M, Cianciulli P, Coggi G, Forni GL, Magnano C, Meo A, Gramiglioli R, Rebulla P, Fiorelli G, Cappellini MD; Cooleycare Cooperative Group. Clinical and histological characterization of liver disease in patients with transfusion-dependent beta-thalassemia. A multicenter study of 117 cases Haematologica, 2004 Oct; 89(10):1179-86
